Boc groups as protectors and directors for Ir-catalyzed C-H borylation of heterocycles.
نویسندگان
چکیده
Ir-catalyzed C-H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C-H positions beta to N. The Boc group can be removed on thermolysis or left intact during subsequent transformations.
منابع مشابه
A traceless directing group for C-H borylation.
Not a trace: Borylation of the nitrogen in nitrogen heterocycles or anilines provides a traceless directing group for subsequent catalytic C-H borylation. Selectivities that previously required Boc protection can be achieved; furthermore, the NBpin directing group can be installed and removed in-situ, and product yields are substantially higher. Boc=tert-butoxycarbonyl, pin=pinacolato.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 74 23 شماره
صفحات -
تاریخ انتشار 2009